Chameleon Twist 2 is a video game developed by Japan System Supply and published by Sunsoft for the Nintendo 64 released in 1998. It is the sequel to Chameleon Twist.

The story of Chameleon Twist 2 takes place after the events in Chameleon Twist. Davy and his friends (Jack, Fred, and Linda) are playing in the forest, still carrying the backpack from his last adventure, when suddenly the rabbit (closely resembling Lewis Carroll’s White Rabbit) from before falls down and knocks one of the chameleons into the sky. The chameleon transforms into an enhanced-looking humanoid chameleon and goes on a search for six carrots in six different worlds.